Anastasia L Sowers Selected Research

tempol

1/2022	The antioxidant tempol transforms gut microbiome to resist obesity in female C3H mice fed a high fat diet.
5/2015	The nitroxide radical TEMPOL prevents obesity, hyperlipidaemia, elevation of inflammatory cytokines, and modulates atherosclerotic plaque composition in apoE-/- mice.
9/2012	The antioxidant tempol reduces carcinogenesis and enhances survival in mice when administered after nonlethal total body radiation.
7/2012	Pharmacological protection from radiation ± cisplatin-induced oral mucositis.
8/2010	Inhibition of adipogenesis by Tempol in 3T3-L1 cells.
8/2007	Differential radiation protection of salivary glands versus tumor by Tempol with accompanying tissue assessment of Tempol by magnetic resonance imaging.
10/2005	Kinetics of tempol for prevention of xerostomia following head and neck irradiation in a mouse model.
1/2003	A low molecular weight antioxidant decreases weight and lowers tumor incidence.

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Anastasia L Sowers Research Topics

Disease

22	Neoplasms (Cancer) 02/2024 - 01/2003
6	Squamous Cell Carcinoma of Head and Neck 02/2023 - 07/2013
5	Carcinogenesis 01/2023 - 01/2003
5	Head and Neck Neoplasms (Head and Neck Cancer) 01/2016 - 03/2004
4	Squamous Cell Carcinoma (Epidermoid Carcinoma) 07/2015 - 02/2004
3	Obesity 01/2022 - 08/2010
3	Inflammation (Inflammations) 05/2015 - 06/2004
2	Hematologic Neoplasms (Hematological Malignancy) 01/2018 - 09/2012
2	Body Weight (Weight, Body) 09/2012 - 08/2010
2	Ulcer 07/2012 - 07/2005
1	Weight Gain 01/2022
1	Non-Small-Cell Lung Carcinoma (Carcinoma, Non-Small Cell Lung) 01/2021
1	Colonic Neoplasms (Colon Cancer) 01/2021
1	Atherosclerosis 05/2015
1	Atherosclerotic Plaque (Atheroma) 05/2015
1	Hepatomegaly 08/2013
1	Liver Diseases (Liver Disease) 08/2013
1	Second Primary Neoplasms (Neoplasms, Second) 09/2012
1	Lymphoma (Lymphomas) 09/2012
1	Stomatitis 07/2012
1	Weight Loss (Weight Reduction) 08/2010
1	Radiation Fibrosis Syndrome (Radiation Fibrosis) 08/2009
1	Contracture 08/2009
1	Fibrosis (Cirrhosis) 08/2009
1	Hypoxia (Hypoxemia) 04/2007
1	Xerostomia 10/2005

Drug/Important Bio-Agent (IBA)

8	tempolIBA 01/2022 - 01/2003
5	nitroxylIBA 01/2022 - 01/2003
4	Proteins (Proteins, Gene)FDA Link 02/2023 - 01/2016
4	AntioxidantsIBA 01/2022 - 01/2003
3	Biomarkers (Surrogate Marker)IBA 01/2021 - 08/2009
3	CytokinesIBA 07/2015 - 08/2013
3	carbogenIBA 04/2007 - 02/2004
2	Messenger RNA (mRNA)IBA 02/2024 - 08/2013
2	Tumor Necrosis Factor-alpha (Tumor Necrosis Factor)IBA 02/2023 - 08/2013
2	birinapantIBA 02/2023 - 01/2016
2	Phosphotransferases (Kinase)IBA 02/2023 - 04/2010
2	Anti-Bacterial Agents (Antibiotics)IBA 01/2023 - 01/2022
2	Fatty Acids (Saturated Fatty Acids)IBA 01/2022 - 08/2013
2	Oxygen (Dioxygen)IBA 04/2007 - 02/2004
2	Contrast MediaIBA 04/2006 - 11/2004
1	Proteasome Endopeptidase Complex (Proteasome)IBA 01/2023
1	Deubiquitinating EnzymesIBA 01/2023
1	UbiquitinIBA 01/2023
1	Aldehyde DehydrogenaseIBA 01/2022
1	Angiopoietin-Like Protein 4IBA 01/2022
1	Bile Acids and Salts (Bile Acids)IBA 01/2022
1	NucleotidesIBA 01/2021
1	(2,4- dihydroxy- 5- isopropylphenyl)- (5- (4- methylpiperazin- 1- ylmethyl)- 1,3- dihydroisoindol- 2- yl)methanoneIBA 01/2021
1	Amifostine (Ethyol)FDA LinkGeneric 01/2018
1	Small Interfering RNA (siRNA)IBA 01/2016
1	NG-Nitroarginine Methyl Ester (L-NAME)IBA 07/2015
1	MorpholinosIBA 07/2015
1	Nitric Oxide (Nitrogen Monoxide)FDA Link 07/2015
1	Interleukin-2 (IL2)IBA 07/2015
1	Interleukin-10 (Interleukin 10)IBA 07/2015
1	gedatolisibIBA 06/2015
1	Adenosine Triphosphate (ATP)IBA 06/2015
1	Apolipoproteins E (ApoE)IBA 05/2015
1	AdipokinesIBA 05/2015
1	N,N-dimethylarginine (asymmetric dimethylarginine)IBA 08/2013
1	CytochromesIBA 08/2013
1	AlbuminsIBA 08/2013
1	GlobulinsIBA 08/2013
1	AcidsIBA 08/2013
1	Niacinamide (Nicotinamide)FDA LinkGeneric 08/2013
1	Phospholipids (Phosphatides)FDA LinkGeneric 08/2013
1	Triglycerides (Triacylglycerol)IBA 08/2013
1	Transforming Growth Factors (Transforming Growth Factor)IBA 08/2013
1	N-caproylglycineIBA 08/2013
1	2- amino- 8- (4- (2- hydroxyethoxy)cyclohexyl)- 6- (6- methoxypyridin- 3- yl)- 4- methylpyrido(2,3- d)pyrimidin- 7(8H)- oneIBA 07/2013
1	Transforming Growth Factor-beta Type I ReceptorIBA 07/2013
1	pifithrinIBA 07/2013
1	Phosphatidylinositols (Phosphatidylinositol)IBA 07/2013
1	TOR Serine-Threonine KinasesIBA 07/2013
1	Methionine (L-Methionine)FDA Link 07/2012
1	Cisplatin (Platino)FDA LinkGeneric 07/2012
1	Reactive Oxygen Species (Oxygen Radicals)IBA 11/2011
1	GasesIBA 01/2011
1	Cytidine Monophosphate (CMP)IBA 01/2011
1	LipidsIBA 08/2010
1	Checkpoint Kinase 1IBA 04/2010
1	3- (carbamoylamino)- 5- (3- fluorophenyl)- N- (3- piperidyl)thiophene- 2- carboxamideIBA 04/2010
1	halofuginoneIBA 08/2009
1	Transforming Growth Factor beta (TGF-beta)IBA 08/2009
1	Free RadicalsIBA 08/2007
1	Hydroxylamine (Hydroxylamine Hydrochloride)IBA 08/2007
1	copper (II) diacetyl- di(N(4)- methylthiosemicarbazone)IBA 04/2007
1	fluoromisonidazoleIBA 04/2007
1	NitroimidazolesIBA 04/2007
1	pimonidazoleIBA 04/2007
1	RNA (Ribonucleic Acid)IBA 07/2006
1	Glucose (Dextrose)FDA LinkGeneric 02/2006
1	Tolonium Chloride FDA Link 07/2005
1	Protons (Proton)IBA 07/2005

Therapy/Procedure

9	Radiotherapy 02/2023 - 03/2004
3	Therapeutics 02/2024 - 07/2012
1	Drug Therapy (Chemotherapy) 01/2023
1	Aftercare (After-Treatment) 07/2006
1	Injections 02/2006